About 5% to 10% of all cancers are thought to be strongly related to an inherited gene mutation. Genetic evaluation is a key component in the early detection, diagnosis and treatment of hereditary cancer and genetic testing can provide valuable information about an individual’s risk for cancer. Individuals with a personal and/or family history of cancer or clinical characteristics suggestive of hereditary cancer are candidates for an oncogenetic consultation and cancer risk assessment and possibly genetic testing.
Dr. Rosner is a specialist in Medical Genetics, with expertise in the Medical Genetics of Gastrointestinal Diseases. He serves as the Director of the Clinic for Hereditary Tumors of the Gastrointestinal tract at the Department of Gastroenterology at the Tel Aviv Sourasky Medical Center (Ichilov).
Following an oncogenetic consultation, genetic testing might be recommended for:
An individual with a personal history of colon cancer, breast cancer, ovarian cancer, pancreatic cancer
An individual with a precancerous lesion (advanced gastric or colorectal polyp)
An individual with a family history of colon cancer, breast cancer, ovarian cancer, pancreatic cancer in a first or second degree relative
Genetic testing is also available for anyone who is interested in estimating their genetic cancer risk.
Genetic testing is performed at an accredited experienced private laboratory.
Payment for genetic testing is not included in the price of the consultation and will be made directly to the genetic laboratory.
More about Genetics and Cancer
Carrying a genetic mutation in a cancer susceptibility gene significantly increases lifetime cancer risk. Additionally, there is a chance of up to 50% of passing the genetic mutation to your offspring in each pregnancy.
The past decade has seen significant advances in genetic testing in general, and more specifically, in testing for cancer susceptibility genes. New technologies have resulted in the testing of multiple cancer susceptibility genes simultaneously with results in just weeks.
The detection of a mutation in a cancer susceptibility gene allows the development of a personalized surveillance programs to minimize disease risk, including frequent screening, lifestyle change and prophylactic surgery or medication.
In patients with cancer, the detection of a genetic mutation might influence treatment and provide risk assessment for other cancers.
How are genetic tests performed?
Based on the oncogenetic consultation, genetic testing might be recommended. Your DNA can be tested for a wide variety of genes associated with cancer risk by multigene panel, exome sequencing or genome sequencing.
When the results of the genetic testing are received, a summary consultation will be performed to explain the results and discuss recommendations.
Why perform genetic testing?
The results from genetic testing will provide information regarding an increased cancer risk and help to develop a personalized surveillance and management plan.
Genetic findings might help other family members make informed decisions regarding genetic counseling and testing and may prevent passing the gene mutation to future generations.
In patients with cancer, the results from genetic testing can optimize treatment.